Hydrochloric Acid → HCID 58124835, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 250 mg of 10j in 6 ml of dioxane was mixed with a solution of 120 mg of KOH in 1 ml of water and the reaction mixture was stirred for 5 h at 45° C. The mixture was diluted with 20 ml of water and acidified to pH3 with 0.5N HCl. The product was extracted into ethyl acetate. The organic layer was washed twice with water, dried and concentrated, to give 220 mg of amorphous 10k.

Provenance & Evidence