Water → HCID 58124931, compound

Participants

Reaction Steps

A solution of 32 mg of 10n in 200 μl of pyridine was treated with 30 μl of Ac2O and 1 mg of DMAP and was stirred at RT for 1 hr. Then, 2 ml of water was added and stirring was continued for 1 hr at RT. The mixture was made slightly alkaline by addition of conc. aq. NH4OH and was extracted with ethyl acetate. The organic layer was washed with a small amount of sat. NaCl, dried, concentrated and treated with diisopropyl ether, to give 30 mg of white crystalline 10p. Mp: 225-226° C.; Rf 0.40 (CH2Cl2/acetone 1/1). MS-ESI: [M+1] 541.12.

Provenance & Evidence