Water → HCID 50938977, compound

Participants

Reaction Steps

To 32 mg of 10q in 200 μl of pyridine 30 μl of acetic anhydride and 1 mg of DMAP were added. The mixture was stirred for ½ hr, then water and ethyl acetate were added and stirring was continued for ½ hr at RT. The product was extracted into ethyl acetate and washed twice with water, dried, concentrated and the residues were treated with diethyl ether to provide 25 mg of 10r, as white crystalline material. Mp: 178-180° C. Rf 0.15 (heptane/acetone 1/1). NMR (CDCl3) δ 1.33 (bm, 6, N-isoC3H7), 1.90+1.94 (2×s, 6, 2×CH3-pyrrazole), 2.00 (s, 3, N—CH3), 3.70 (s, 3, NCH3), 3.80 (s, 3, OCH3), 4.65 (m, 1, CH isoC3H7), 6.79 and 6.89 (2×s, 2, ArH), 6.93, 7.08 and 7.36 (3×m, 3, thiophene).

Provenance & Evidence