HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylmorpholine → HCID 66919717, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylmorpholine | HCID 7525 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 4,4,4-Trifluorobutanoic acid | HCID 2777085 | — |
| Reactant | HCID 58124924 | HCID 58124924 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 66919717 | HCID 66919717 | — |
Reaction Steps
A suspension of 26 mg of 10q, 10 mg of trifluorobutyric acid, 15 μl of N-ethyl morpholine and 20 mg of TBTU was stirred at RT for 1 hr. The turbid mixture readily became homogeneous. After one hour, water and ethyl acetate were added and the mixture was stirred for ½ hr. The organic layer was once washed with 1N NaOH and twice with 5% aq. NH4Cl, dried and concentrated. The residue was treated with diethyl ether, from which 25 mg of 10t crystallized, Mp: 256-258° C. Rf 0.25 (heptane/acetone). MS-ESI: [M+1] 654.18
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08431564B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-0f3e611b96524f409fe5077e899048a9 |
| Source note | uspto-grants-2013_04 |