Potassium Carbonate → HCID 58124849, compound

Participants

Reaction Steps

To 150 mg of 12e in 3 ml of methanol was added 250 mg of dimethyl 1-diazo-2-oxopropylphosphonate and 250 mg of K2CO3. The mixture was stirred at RT overnight. Then reaction was diluted with water and the product was extracted with ether. The extract was washed once with sat. NaCl, dried, concentrated and filtered over a short silica column, using a pentane-ether gradient as eluent, to give 130 mg of 12f as colorless oil; Rf 0.55 (heptane/ether 3/1). NMR (CDCl3) δ 1.33 (s, 3, 2×CH3), 1.48 (s, 9, tertC4H9), 1.92 (t, 1, acetylene-H), 2.10 (m, 4, CH2CH2), 2.88 (s, 3, NCH3).

Provenance & Evidence