HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → HCID 58124916, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 2-Iodothiophene | HCID 18921 | — |
| Reactant | HCID 58124849 | HCID 58124849 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 58124916 | HCID 58124916 | — |
Reaction Steps
A mixture of 130 mg of 12f, 100 μl of piperidine, 75 μl of 2-iodothiophene, 10 mg of CuI and 14 mg of PdCl2(PPh3)2 in 2 ml of degassed toluene was stirred under N2 for 3 hr. The reaction mixture was diluted with 20 ml of ethyl acetate and washed with water, dried and concentrated. The crude material was purified by chromatography over a silica column, using a gradient of pentane/diethyl ether as eluent. This provided 130 mg of 12g as colorless oil; Rf 0.60 (heptane/ether 3/1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08431564B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-2d25f7a8a1854aea99f9992f47317a73 |
| Source note | uspto-grants-2013_04 |