Hydrochloric Acid → HCID 66919870, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 110 mg of 12i in 3 ml of dioxane a solution of 50 mg of KOH in 1 ml of water was added. The mixture was stirred at 50° C. for 2 hr. After cooling to RT, 15 ml of water was added and the reaction mixture was acidified to pH3 by addition of cold 0.5 N HCl. The product was extracted into ethyl acetate. The extract was once washed with water, dried and concentrated, to provide 100 mg of the acid 12j as colorless amorphous material, used without further purification in the next step; MS-ESI: [M+1] 546.98, 548.98).

Provenance & Evidence