Hydrochloric Acid → HCID 58124947, compound

Participants

Reaction Steps

To a suspension of 110 mg of 14d in 300 μl of dioxane was added 400 μl of a solution of 4N HCl in dioxane. A clear solution readily formed. The reaction mixture was stirred for 1 h. Then, 3 ml of a 1/1 mixture of ethyl acetate and diethyl ether was added. The precipitate was filtered and dried, to give 95 mg of white crystalline 14e; Mp 242-243° C. MS-ESI: [M+1] 480.14. NMR (CDCl3+CD3OD) δ 1.13 (d, 6,0-isoC3H7), 1.33 (d, 6, isoC3H7), 3.85 (s, 3, OCH3), 3.95 (m, 1, isoC3H7), 4.65 (m, 1, isoC3H7), 6.67 and 6.72 (2×s, H7 and H10), 7.18, 7.21 and 7.44 (3×m, 3, thiophene). hFSHRago (CHO luc) pEC50=7.03.

Provenance & Evidence