Sodium Hydroxide → 2-Formyl-5,6-dihydro-8-methoxy-9-(1-methylethoxy)-1-(2-thienyl)pyrrolo[2,1-a]isoquinoline-3-carboxylic acid

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Reaction Conditions

Reaction Steps

A solution of 815 mg of 15c in 40 ml of ethanol was mixed with 18 ml of 2N NaOH. The mixture was stirred for 1 h at 60° C. The mixture was cooled and concentrated to half its original volume and diluted with 30 ml of water, acidified with 0.5N NaOH and extracted with ethyl acetate. The organic extract was washed with water, dried and concentrated to provide 750 mg of 15d as an amorphous material, which was used without further purification in the next step.

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