HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 50939245, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 58124808 | HCID 58124808 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 50939245 | HCID 50939245 | 51.1% |
Reaction Steps
A mixture of 55 mg of 15e and 100 μl of DiPEA in 0.5 ml of THF and 0.1 ml of NMP was treated with 50 mg of HATU. The mixture was stirred overnight and then diluted with 5 ml of water and extracted with ethyl acetate. The extract was washed with water, dried, concentrated and the crude material was purified by chromatography over silica gel, using a gradient of heptane/ethyl acetate, to provide 27 mg of 15f. MS-ESI:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08431564B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-0355a4dab8c74a4f95c6ba46fd200ea3 |
| Source note | uspto-grants-2013_04 |