Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | HCID 58124840 | HCID 58124840 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 66919834 | HCID 66919834 | 94.9% |
Reaction Steps
A solution of 530 mg of 16k in 9 ml of dioxane was mixed with a solution of 300 mg of KOH in 3 ml of water and stirred at 55° C. for ½ hr. The reaction mixture was diluted with 25 ml of water and acidified with 0.5N HCl to pH3 and the product was extracted with ethyl acetate. The extract was once washed with water, dried and concentrated, to give 480 mg of 16l as colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08431564B2 |
|---|
| Source dataset | uspto-grants-2013_04 |
|---|
| ORD ID | ord-7d517c199bde4608b331d51b068c662a |
|---|
| Source note | uspto-grants-2013_04 |
|---|
