Hydrochloric Acid → HCID 66919817, compound

Participants

Reaction Steps

A solution of 12 mg of 16m, 6 mg of pyridine-3-boronic acid, 10 mg of K2CO3, 1.5 ml of degassed dimethoxyethane, 100 μl of water and 5 mg of Pd(PPh3)4 was heated at 90° C. for 4 hr under a N2 atmosphere. The mixture was cooled and poured into 10 ml of 2N NaOH and extracted with ethyl acetate. The extract was washed once with water, dried and chromatographed using a gradient of heptane/acetone as eluent. The material thus isolated was taken up in 200 μl of CH2Cl2 and treated with 0.2N HCl in diethyl ether, to pH slight acidic, to provide 12 mg of 16n as a yellowish HCl salt, MS-ESI:

Provenance & Evidence