Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Ethyl 7-bromo-2-(2-(tert-butyl(6-(thiazol-5-yl)hex-5-ynyl)amino)-2-oxoacetyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylate | HCID 58124843 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 58124897 | HCID 58124897 | 83.9% |
Reaction Steps
A solution of 300 mg of 17g in 3 ml of dioxane was mixed with 130 mg of KOH in 1 ml of water. The mixture was stirred at 50° C. for 1.5 hr, cooled, diluted with 20 ml of water, acidified to pH3 (0.2N HCl) and extracted with ethyl acetate. The extract was washed twice with water, dried and concentrated, to give 240 mg of acid 17h as a colorless foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08431564B2 |
|---|
| Source dataset | uspto-grants-2013_04 |
|---|
| ORD ID | ord-7b1ab5b5208444a5b4940ccdd0683ab8 |
|---|
| Source note | uspto-grants-2013_04 |
|---|
