Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | HCID 58124816 | HCID 58124816 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 58124953 | HCID 58124953 | 99.9% |
Reaction Steps
A solution of 280 mg of 18a in 4 ml of dioxane was mixed with 140 mg of KOH in 0.8 ml of water and stirred at 60° C. for 5 hr. The reaction mixture was cooled, diluted with 10 ml of water and acidified with cold 0.5N HCl. The product was extracted with ethyl acetate. The extract was washed twice with water, dried and concentrated, to give 264 mg of 18b as a colorless foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08431564B2 |
|---|
| Source dataset | uspto-grants-2013_04 |
|---|
| ORD ID | ord-e386fb21c0954a199c3f08e24446b3b7 |
|---|
| Source note | uspto-grants-2013_04 |
|---|
