Potassium Carbonate → HCID 58124828, compound

Participants

Reaction Steps

A solution of 50 mg of 18d, 60 mg of K2CO3, 20 mg of 3-pyridylboronic acid and 15 mg of Pd(PPh3)4 in 2.5 ml of degassed 90% aq. dimethoxyethane was heated at 95° C. under N2 for 16 hr. The reaction mixture was cooled and poured into 1N NaOH. The product was extracted with ethyl acetate. The organic extract was washed twice with water, dried, concentrated and the residue was chromatographed over silica gel, using a gradient of heptane/acetone as eluent. The product thus isolated was treated with diethyl ether, to provide 28 mg of 18e as white crystalline material. Mp 193-194° C.

Provenance & Evidence