Potassium Carbonate → HCID 66919922, compound

Participants

Reaction Steps

A solution of 50 mg of 18d, 60 mg of K2CO3, 30 mg of 4-pyridylboronic acid-pinacolester and 15 mg of Pd(PPh3)4 in 2.5 ml of degassed 90% aq. dimethoxyethane was heated at 95° C. under N2 for 16 hr. The mixture was cooled and poured onto 1N NaOH and the product was extracted with ethyl acetate. The organic layer was washed twice with water, dried, concentrated and the residue was chromatographed on silica gel (using a gradient of heptane/acetone as eluent). The product was treated with ether, to give 25 mg of 18f as white crystals. Mp: 218-219° C. MS-ESI: [M+1] 490.17.

Provenance & Evidence