p-Toluenesulfonic acid → HCID 86650573, compound

Participants

Reaction Steps

A solution of 868 mg of 21c in 10 ml of acetone, 2.2 ml of 2,2-dimethoxypropane, and 17 mg of p-toluenesulfonic acid was stirred for 2 hr. The reaction was treated with 0.8 ml of triethylamine, stirred for 5 min, and then concentrated to a small volume and diluted with 30 ml of 5% NaHCO3 solution. The product was extracted with ethyl acetate and the extracts were washed with water, dried and concentrated, to provide 940 mg of product 21d, which was used as is in the next step; Rf (heptane/ethyl acetate 1/1) 0.57.

Provenance & Evidence