Dimethylamine → HCID 58124847, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 392 mg of 22a in 3 ml of DMF was treated with 0.5 ml of triethylamine and 2 ml of a 2M solution of dimethylamine in THF. The reaction mixture was sealed and heated at an oil bath at 60° C. for 40 min. The clear solution was poured onto water and extracted with ethyl acetate. The extract was washed, dried and concentrated and the residue was purified by chromatography over silicagel, using a gradient of CH2Cl2-methanol. The material thus isolated was triturated with diethylether, to provide 438 mg of crystalline material.

Provenance & Evidence