Potassium Hydroxide → HCID 58124952, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 250 mg of 24d, 250 mg of KOH, 3 ml of dioxane and 1 ml of water was heated at oil bath at 50° C. for 1 hr. The mixture was poured onto water and extracted once with heptane/ether 1/1. The aqueous phase was acidified with cold 1N HCl to pH3 and extracted with ethyl acetate. The organic extract was once washed with sat. NaCl and dried and concentrated, to give 240 mg of 24e, as colorless oil. NMR (CDCl3) δ 1.00 (s, 6, 2×CH3), 1.50 (s, 9, tertC4H9), 2.00 (t, 1, acetylene), 1.70 (m, 2, CH2), 2.10 (m, 2, CH2), 3.71 (m, 2, CH2).

Provenance & Evidence