Hydrochloric Acid → HCID 58124938, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 430 mg of 24f, 300 mg of KOH, 10 ml of dioxane and 1.5 ml of water was warmed at 60° C. for 1 hr. Reaction was cooled and diluted with 30 ml of water and acidified to pH3 with 0.5 N HCl. The product was extracted into ethyl acetate. The organic extract was washed twice with water, dried and concentrated, to leave 390 mg of 24g, as a colorless oil. Rf (toluene/acetone 1/1) 0.55. NMR (CDCl3) δ 7.70 and 6.65 (2×s, 2, Ar—H), 5.79 (s, 1, CH), 3.90 (s, 3, OCH3), 1.97 (t, 1, acetylene), 0.90 (s, 6, 2×CH3), 1.55 (s, 9, tertC4H9).

Provenance & Evidence