Methanesulfonyl chloride → HCID 58124794, compound

Participants

Reaction Steps

To a solution of 12.5 mg 20b in 2 mL methylene chloride was added 3.2 μL methanesulphonyl chloride and 9.2 μL N,N-diisopropylethylamine. The mixture was stirred at room temperature. After 1 h the mixture was diluted with methylene chloride and was washed with water. The organic phase was dried and concentrated. The crude product was purified by preparative HPLC on a reversed phase C18 column to give 1.8 mg of compound 29a.

Provenance & Evidence