4-Methylmorpholine → HCID 67128323, compound

https://huagongshe.com/reaction/1971767

Participants

Role	Name	HCID	Charge
Reactant	4-Methylmorpholine	HCID 7972	—
Reactant	Benzoic acid, 4-amino-, 1,1-dimethylethyl ester	HCID 233272	—
Reactant	Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)	HCID 9886157	—
Reactant	Acetonitrile--water (1/1)	HCID 18373917	—
Solvent	Dimethylformamide	HCID 6228	—
Product	HCID 67128323	HCID 67128323	—

Reaction Conditions

Temperature	55 °C

Reaction Steps

To 2-(2)-oxopyrrolidin-1-yl propanoic acid (0.95 g, 6.04 mmol) in DMF (5 mL) was added HATU (3.2 g, 8.5 mmol), tert-butyl 4-aminobenzoate (1.2 g, 2.12 mmol) and NMM (1.4 mL, 13.30 mmol). The reaction mixture was stirred at 55° C. for 2 hours and then diluted with Acetonitrile/water (2:1, 30 mL) and the resulting solid was stirred and filtered and washed with water and dried to give tert-butyl 4-(2-(2-oxopyrrolidin-1-yl)propanamido)benzoate which was used for the next step with out purification.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08431610B2
Source dataset	uspto-grants-2013_04
ORD ID	ord-74b41b87181746bc9d9d093a2ae2d358
Source note	uspto-grants-2013_04