HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1971769Generated: November 2, 2026
4-Methylmorpholine → HCID 68779800, compound
https://huagongshe.com/reaction/1971769
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | N1-(tert-Butoxycarbonyl)-4-fluoro-1,2-phenylenediamine | HCID 24688763 | — |
| Reactant | HCID 68776068 | HCID 68776068 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 68779800 | HCID 68779800 | — |
Reaction Steps
To the 4-(2-(2-oxopyrrolidin-1-yl)propanamido)benzoic acid (210 mgs, 0.76 mmol) in DMF (2 mL), was added HATU (375 mg, 0.99 mmol), tert-butyl 2-amino-4-fluorophenylcarbamate (172 mg, 0.76 mmol) and NMM (0.3 mL, 2.3 mmol) and stirred at 55° C. for 40 hours. The reaction mixture was then diluted with water and acetonitrile and the precipitate formed was then filtered, washed with water and dried. The solid was then purified by column chromatography on silica gel with elution using 80% ethyl acetate/hexanes to give tert-butyl 4-fluoro-2-(4-(2-(2-oxopyrrolidin-1-yl)propanamido)benzamido)phenylcarbamate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08431610B2 |
|---|
| Source dataset | uspto-grants-2013_04 |
|---|
| ORD ID | ord-dfb67a63a4d240599b33a78923741697 |
|---|
| Source note | uspto-grants-2013_04 |
|---|
