HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1971772Generated: November 1, 2026
4-Methylmorpholine → HCID 67128469, compound
https://huagongshe.com/reaction/1971772
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Methyl 4-aminobenzoate | HCID 12082 | — |
| Reactant | 2-(2-Oxopyrrolidin-1-yl)propanoic acid | HCID 3018702 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 67128469 | HCID 67128469 | — |
Reaction Steps
To 2-(2-oxopyrrolidin-1-yl)propanoic acid (942 mgs, 6.0 mmol) in DMF (8 mL), was added HATU (2.4 g, 6.4 mmol), 4-Amino-benzoic acid methyl ester (660 mg, 4.0 mmol) and NMM (1.8 mL, 16.0 mmol) and stirred at 55° C. for 16 hours. The reaction mixture was diluted with ethyl acetate (100 mL) and washed with 1 N HCl, saturated NaHCO3, water, brine and dried over MgSO4. Filtration and concentration gave methyl 4-(N-methyl-2-(2-oxopyrrolidin-1-yl)propanamido)benzoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08431610B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-82d84bf0379a49348500162f84e9be63 |
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| Source note | uspto-grants-2013_04 |
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