Hydrochloric Acid → HCID 57912453, compound

Participants

Reaction Steps

After adding ethanol (124 mL) and aqueous 5N sodium hydroxide (11 mL, 55 mmol) in that order to ethyl 3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-methoxypyrazolo[5,1-b][1,3]thiazole-7-carboxylate (2.8 g, 6.89 mmol), the mixture was heated to reflux for 2 hours. Aqueous 5N hydrochloric acid (11 mL) was then added to the mixture while cooling on ice, and the solvent in the mixture was distilled off under reduced pressure. Water was added to the residue, and the precipitated solid was collected by filtration, washed with water and dried under reduced pressure to obtain the title compound (2.52 g, 6.66 mmol).

Provenance & Evidence