HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → HCID 58126934, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 6-Hydroxy-5-oxo-1-(2-oxo-2-piperidin-1-yl-ethyl)-1,5-dihydro-imidazo[1,2-a]pyrimidine-7-carboxylic acid methyl ester | HCID 58126988 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 58126934 | HCID 58126934 | 49.3% |
Reaction Steps
The crude product of example 2 was dissolved in DMF (50 ml) and then K2CO3 (3.3 g, 0.024 mol) was added. After stirring at room temperature for about 0.5 hours, benzyl bromide (4.0 g, 0.0234 mol) was added drop-wise. Then the mixture was heated at 80° C. for another 5 hours. After cooling to room temperature, the solids were filtered off and washed with ethyl acetate. The filtrate was diluted with EA, washed with water and then brine, dried and concentrated. The residue was purified by column chromatography (CH2Cl2/MeOH=50/1) to give the titled compound (2.0 g, 2-step yield 49.3%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08431581B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-f4a304265470460eb1494a1cdf2f4e59 |
| Source note | uspto-grants-2013_04 |