Methanol → 7-[5-[(4-Fluorophenyl)methyl]oxazol-2-yl]-6-hydroxy-1-[2-oxo-2-(1-piperidyl)ethyl]imidazo[1,2-a]pyrimidin-5-one

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Reaction Steps

To a solution of the product of example 6 (50 mg, 0.092 mmol) in acetonitrile (2 ml) was added TMSI (150 mg, 0.75 mmol) drop-wise at room temperature. The mixture was stirred for 8 hours, after which methanol (0.1 ml) was added to quench the reaction. Then saturated solution of Na2S2O3 was added drop-wise till a yellow solid was precipitated. The resulting solids were collected by filtration, washed with ethyl acetate to give the desired product (10 mg, 24% yield).

Provenance & Evidence