反应详情

To a solution of 4-(5-fluoro-2-methoxyphenylsulfonyl)morpholine (0.5 g 1.8 mmol) in CH2Cl2 (10 ml) was added dropwise a solution of tribromoborane (0.593 mg 2.36 mmol) in CH2Cl2 (20 ml) at 0° C. The mixture was stirred at room temperature for 1 h, after which methanol (10 ml) was added to quench the reaction. The solvent was evaporated under reduced pressure and ethyl acetate (30 ml) was added, washed with water and then brine, dried and concentrated into dryness to give the product (427 mg, 90% yield).

1. customto quench
2. customthe reaction
3. customThe solvent was evaporated under reduced pressure and ethyl acetate (30 ml)
4. additionwas added
5. washwashed with water
6. dry with materialbrine, dried
7. concentrationconcentrated into dryness