Trifluoromethanesulfonic anhydride → Trifluoro-methanesulfonic acid 4-fluoro-2-(morpholine-4-sulfonyl)-phenyl ester

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Reaction Steps

To a solution of 4-fluoro-2-(morpholinosulfonyl)phenol (0.4 g, 1.5 mmol) and DMAP (0.28 g 2.29 mmol) in CH2Cl2(10 ml), Tf2O (0.93 ml 5.5 mmol) was added dropwise at 0° C. The mixture was stirred at room temperature for 4 h, after which the mixture was washed with hydrochloric acid (1N, 20 ml) and then extracted with EA. The extracts were combined, washed with brine, dried over sodium sulfate and evaporated into dryness. The resulting residue was purified by column chromatography using PE/EA (10/1) as eluent to give the desired product (469 mg, yield 78%).

Provenance & Evidence