HCID 58126879, compound → HCID 58126952, compound

HRID 1971847Notes

Reaction equation

HRID 1971847 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][OH:11])=[C:4]([S:12]([CH3:15])(=[O:14])=[O:13])[CH:3]=1.[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>ClCCl>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH:10]=[O:11])=[C:4]([S:12]([CH3:15])(=[O:14])=[O:13])[CH:3]=1

Participants

4

Reactant 2

HCID 58126879HCID 58126879, compoundHCID 178418287HCID 178418287, compound

Product 1

HCID 58126952HCID 58126952, compoundYield 58%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To the solution of the product of example 133 (1.0 g, 4.3 mmol) in dichloromethane (100 ml), was added Pyridinium Chlorochromate (1.65 g 6.4 mmol) at 0° C. The mixture was stirred at room temperature for 5 hours. The result mixture was washed with water, and the organic layer was dried over Na2SO4. The product was purified by column chromatography to give the titled compound (555 mg, yield 58%)

Workup

  1. washThe result mixture was washed with water
  2. dry with materialthe organic layer was dried over Na2SO4
  3. customThe product was purified by column chromatography

Sources & evidence

ORD record
ord-7a7af2062f67458eb4a885c497d1efbd
Source dataset
uspto-grants-2013_04
Patent number
US08431581B2

Reaction notes

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