Water → HCID 58126905, compound

Participants

Reaction Steps

To a solution of the product of example 117 (15 mg, 0.024 mmol) in DMF (0.5 ml), POCl3 (0.1 ml) was added drop-wise. The mixture was stirred at room temperature for 20 hours, after which water was added, and then extracted with CH2Cl2. The extracts were combined, washed with brine, and then dried over sodium sulfate. The product was purified by column chromatography (CH2Cl2/EA/MeOH=8/2/1) to give the desired product (6 mg, 40% yield).

Provenance & Evidence