HCID 16753952, compound → HCID 58126883, compound

Participants

Reaction Steps

1-[2-((2R,6R)-2,6-Dimethyl-morpholin-4-yl)-2-oxo-ethyl]-3-(1,1-dioxo-1lambda*6*-isothiazolidin-2-yl)-6-hydroxy-5-oxo-1,5-dihydro-imidazo[1,2-a]pyrimidine-7-carboxylic acid methyl ester (30 mg, 0.062 mmol) was dissolved in MeOH (1 mL) and 2-aminomethyl-5-fluoro-N,N-dimethyl-benzenesulfonamide (22 mg, 0.093 mmol) was added. The reaction was heated at reflux for 24 hours then filtered hot and the filtrate concentrated. The product was recrystalised from methanol and ether and isolated (17 mg, 43% yield) as a pale yellow solid.

Provenance & Evidence