HCID 16753952, compound → HCID 58126914, compound

HRID 1971856Notes

Reaction equation

C[O:2][C:3]([C:5]1[N:6]=[C:7]2[N:15]([CH2:16][C:17]([N:19]3[CH2:24][CH:23]([CH3:25])[CH2:22][CH:21]([CH3:26])[CH2:20]3)=[O:18])[CH:14]=[C:13]([CH2:27][S:28][CH3:29])[N:8]2[C:9](=[O:12])[C:10]=1[OH:11])=O.[NH2:30][CH2:31][C:32]1[CH:37]=[CH:36][C:35]([F:38])=[CH:34][C:33]=1[S:39]([N:42]([CH3:44])[CH3:43])(=[O:41])=[O:40]>>[CH3:43][N:42]([CH3:44])[S:39]([C:33]1[CH:34]=[C:35]([F:38])[CH:36]=[CH:37][C:32]=1[CH2:31][NH:30][C:3]([C:5]1[N:6]=[C:7]2[N:15]([CH2:16][C:17]([N:19]3[CH2:20][CH:21]([CH3:26])[CH2:22][CH:23]([CH3:25])[CH2:24]3)=[O:18])[CH:14]=[C:13]([CH2:27][S:28][CH3:29])[N:8]2[C:9](=[O:12])[C:10]=1[OH:11])=[O:2])(=[O:41])=[O:40]

Participants

Reactant 2

HCID 16753952HCID 16753952, compound

HCID 58126903HCID 58126903, compound

Product 1

HCID 58126914HCID 58126914, compoundYield 84.7%

Procedure

Following the same procedure for Example 187 but using 1-[2-(3,5-dimethyl-piperidin-1-yl)-2-oxo-ethyl]-6-hydroxy-3-methylsulfanylmethyl-5-oxo-1,5-dihydro-imidazo[1,2-a]pyrimidine-7-carboxylic acid methyl ester Example 191 and 2-aminomethyl-5-fluoro-N,N-dimethyl-benzenesulfonamide, the title product was obtained in 84.7% yield as a yellowish amorphous solid.

Sources & evidence

ORD record: ord-8f88ccf3785040809d8020b31bb6add1
Source dataset: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08431581B2

Reaction notes

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