HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 86657826, compound → Tert-butyl 3-(aminomethyl)-4,4-difluoropiperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 86657826 | HCID 86657826 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Tert-butyl 3-(aminomethyl)-4,4-difluoropiperidine-1-carboxylate | HCID 67373803 | — |
Reaction Steps
A mixture of 3-azidomethyl-4,4-difluoro-piperidine-1-carboxylic acid tert-butyl ester (1.1 mmol, 300 mg) and 10% palladium on carbon (60 mg) in EtOAc (8 mL) was stirred under an atmosphere of H2 for 2 hrs, filtered through celite, and concentrated to provide 3-aminomethyl-4,4-difluoro-piperidine-1-carboxylic acid tert-butyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08431575B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-37c2cf479b7c432c801b4c2b1d5bbc4e |
| Source note | uspto-grants-2013_04 |