HRID1972083

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID20443148

1,4-Dioxane hydrochloride

C4H9ClO2

结构：CCCCc1nnc(C(=O)NC[C@H]2CCN(C(=O)OC(C)(C)C)C[C@H]2F)cc1-c1ccc(OC2CCCCC2)cc1

HCID86657838

未命名化合物

PRODUCTS

生成物

结构：CCCCc1nnc(C(=O)NC[C@H]2CCNC[C@H]2F)cc1-c1ccc(OC2CCCCC2)cc1.Cl.Cl

HCID131730542

未命名化合物

PROCEDURE

实验过程

(±)-cis-4-({[6-Butyl-5-(4-cyclohexyloxy-phenyl)-pyridazine-3-carbonyl]-amino}-methyl)-3-fluoro-piperidine-1-carboxylic acid tert-butyl ester (0.47 mmol, 266 mg) was stirred in 4 M HCl/dioxane (2 mL) for 20 min at room temperature. The solvent was evaporated to provide (±)-cis-6-butyl-5-(4-cyclohexyloxy-phenyl)-pyridazine-3-carboxylic acid (3-fluoro-piperidin-4-ylmethyl)-amide dihydrochloride. The crude product was used without further purification.

WORKUP

后处理

customThe solvent was evaporated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-41e693f99e9e46aea0784cbba09124f2
来源数据集: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08431575B2
来源说明: uspto-grants-2013_04

反应 SMILES

C(OC([N:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][NH:15][C:16]([C:18]2[N:19]=[N:20][C:21]([CH2:37][CH2:38][CH2:39][CH3:40])=[C:22]([C:24]3[CH:29]=[CH:28][C:27]([O:30][CH:31]4[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]4)=[CH:26][CH:25]=3)[CH:23]=2)=[O:17])[C@H:10]([F:41])[CH2:9]1)=O)(C)(C)C.[ClH:42].O1CCOCC1>>[ClH:42].[ClH:42].[F:41][C@H:10]1[C@@H:11]([CH2:14][NH:15][C:16]([C:18]2[N:19]=[N:20][C:21]([CH2:37][CH2:38][CH2:39][CH3:40])=[C:22]([C:24]3[CH:29]=[CH:28][C:27]([O:30][CH:31]4[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]4)=[CH:26][CH:25]=3)[CH:23]=2)=[O:17])[CH2:12][CH2:13][NH:8][CH2:9]1