HCID 57721343, compound → HCID 66916754, compound

HRID 1972116Notes

Reaction equation

HRID 1972116 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[N:8]=[CH:7][CH:6]=[CH:5][C:4]=2[C:3]=1[C:12]([OH:14])=O.[F:15][C:16]1([F:33])[CH2:21][CH2:20][N:19]([CH:22]([C:25]2[CH:26]=[N:27][C:28]([S:31][CH3:32])=[N:29][CH:30]=2)[CH2:23][NH2:24])[CH2:18][CH2:17]1>>[F:33][C:16]1([F:15])[CH2:21][CH2:20][N:19]([CH:22]([C:25]2[CH:26]=[N:27][C:28]([S:31][CH3:32])=[N:29][CH:30]=2)[CH2:23][NH:24][C:12]([C:3]2[C:4]3[CH:5]=[CH:6][CH:7]=[N:8][C:9]=3[CH:10]=[CH:11][C:2]=2[Cl:1])=[O:14])[CH2:18][CH2:17]1

Participants

3

Reactant 2

HCID 57721343HCID 57721343, compoundHCID 58227934HCID 58227934, compound

Product 1

HCID 66916754HCID 66916754, compound

Procedure

Compound 582, 6-chloro-quinoline-5-carboxylic acid [2-(4,4-difluoro-piperidin-1-yl)-2-(2-methylsulfanyl-pyrimidin-5-yl)-ethyl]-amide was prepared analogous to Example B.30 by coupling 6-chloro-quinoline-5-carboxylic acid and 2-(4,4-difluoro-piperidin-1-yl)-2-(2-methylsulfanyl-pyrimidin-5-yl)-ethylamine.

Sources & evidence

ORD record
ord-037ee4394c8b49c6a231ebbd89e0964f
Source dataset
uspto-grants-2013_04
Patent number
US08431704B2

Reaction notes

Loading…