Aluminum → Melphalan

Participants

Reaction Steps

Place 200˜1000 g of Melphalan HCl (IM1036) into the vacuum flask, and quickly mount the vacuum flask to a Lyophilizer with the pressure preset at 225 mmHg and temperature at <−40° C. The freeze-drying process is continued overnight until the water content meets the specification requirement. The vacuum is released and the product is weighed. The product is packed in polypropylene bags inside a sealed aluminum pouch and stored at 2˜8° C. in a refrigerator, to protect it from light and moisture. The yield is 96˜99% of theoretical yield.

Provenance & Evidence