Thiourea → 1-(4-(2-Aminothiazol-4-yl)piperidin-1-yl)ethanone

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Reaction Steps

1-(1-acetylpiperidin-4-yl)-2-bromoethanone (2.37 g, 9.561 mmol) and thiourea (0.728 g, 9.561 mmol) were dissolved in ethanol (40 mL) and agitated at ambient temperature for 30 minutes. The mixture was heated to 80° C. and agitated an additional 1 hour. Upon cooling solvent was evaporated and the residue was distributed between 20 mL of 2M NaOH and 20 mL of chloroform. The organic phase was separated and discarded. The remaining aqueous phase (white slurry) was extracted with chloroform until all solids were extracted (4×200 mL). The organic extracts were combined, dried over magnesium sulfate and evaporated to give the desired product (1.600 g, 74.27% yield) as white solid.

Provenance & Evidence