Potassium Phosphate, Tribasic → HCID 67486552, compound

Participants

Reaction Conditions

Reaction Steps

3-(2-Chloropyridin-4-yloxy)-2-methylpyridine (4.8 g, 21.8 mmol), tert-butyl carbamate (6.37 g, 54.4 mmol), and potassium phosphate (5.08 g, 23.9 mmol) were added to degassed toluene (100 mL). 9,9-Dimethyl-4,5-bis(diphenylphosphino)xanthene (0.944 g, 1.63 mmol), tris(dibenzylideneacetone)-dipalladium (0.996 g, 1.09 mmol) and degassed water (25 mL) were added, and the reaction was stirred at 90° C. for 3 days. The reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was dried, concentrated, and flash chromatographed (10-50% ethyl acetate/hexanes) to give the title compound (5.5 g, 59% yield) as a light yellow solid.

Provenance & Evidence