Triethylamine → HCID 86640988, compound

Participants

Reaction Conditions

Reaction Steps

1-(5-Bromo-4-(2-methylpyridin-3-yloxy)pyridin-2-yl)thiourea (1.48 g, 4.4 mmol), tert-butyl 4-(2-bromoacetyl)piperidine-1-carboxylate (1.41 g, 4.60 mmol, prepared from 1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid utilizing the procedure from Example 1, steps A-C), and triethylamine (0.93 mL, 6.56 mmol) were diluted in ethanol (130 mL). The reaction was stirred at 70° C. overnight and then concentrated. Water was added and the solution was extracted with ethyl acetate, dried and concentrated to give the title compound (2.37 g, 94% yield) as light yellow solid.

Provenance & Evidence