Sodium Hydroxide → HCID 86653822, compound

Participants

Reaction Steps

Ethyl(S)-2-(N-acetylamino)-5-bromooctanate (3.9 g) was dissolved in EtOH and 12.7 ml (1 eq) of 1N NaOH was added every 1 hour in the total amount of 50.8 ml (4 eq), followed by stirring overnight. After concentration, the aqueous layer was washed by liquid separation using diethylether. The pH of the aqueous layer was adjusted to about 1 to 2 using 1N HCl, followed by extraction with diethylether. The diethylether layer was washed with brine and dehydrated over sodium sulfate. After concentration, 3.9 g (86.3%) of 2-(N-acetylamino)-5-bromooctanoic acid was obtained as a white solid.

Provenance & Evidence