HCID 59485683, compound → HCID 59485882, compound

HRID 1972213Notes

Reaction equation

HRID 1972213 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[C:5]([CH:9]2[CH2:13][O:12][C:11](=[O:14])[NH:10]2)[CH:6]=[CH:7][CH:8]=1.Br[C:18]1[CH:23]=[N:22][C:21]([O:24][C:25]2[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=2)=[CH:20][N:19]=1>>[Cl:31][C:28]1[CH:29]=[CH:30][C:25]([O:24][C:21]2[N:22]=[CH:23][C:18]([N:10]3[C@@H:9]([C:5]4[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:1])([F:15])[F:16])[CH:4]=4)[CH2:13][O:12][C:11]3=[O:14])=[N:19][CH:20]=2)=[CH:26][CH:27]=1

Participants

3

Reactant 2

HCID 59485683HCID 59485683, compoundHCID 65585953HCID 65585953, compound

Product 1

HCID 59485882HCID 59485882, compound

Procedure

(S)-3-[5-(4-Chloro-phenoxy)-pyrazin-2-yl]-4-(3-trifluoromethyl-phenyl)-oxazolidin-2-one is prepared from 4-(3-trifluoromethyl-phenyl)-oxazolidin-2-one and 2-bromo-5-(4-chloro-phenoxy)-pyrazine using the same conditions as example 4. 1H NMR (CDCl3, 400 MHz) δ 8.98 (d, 1H), 7.95 (d, 1H), 7.47˜7.62 (m, 4H), 7.34 (d, 2H), 7.04 (d, 2H), 5.82 (dd, 1H), 4.88 (t, 1H), 4.35 (dd, 1H); HPLC-MS calculated for C20H13ClF3N3O3 (M+H+) 436.1, found 436.1.

Sources & evidence

ORD record
ord-1c8085faf46f4560825cf3871229ea05
Source dataset
uspto-grants-2013_04
Patent number
US08431607B2

Reaction notes

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