HCID 59485644, compound → HCID 59485721, compound

Participants

Reaction Steps

A solution of (S)-2-(3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)-phenyl)imidazolidin-1-yl)-N,N-bis(4-methoxybenzyl)ethanesulfonamide (2.2 g, 2.82 mmol) in TFA (30 mL) is stirred at room temperature for 14 h. Excess of TFA is removed under vacuum. The residue is treated with saturated NaHCO3 aqueous solution (30 mL) and extracted with EtOAc (3×50 mL). The combined organic layer is washed with brine and dried (MgSO4). After removing the drying agent, the solution is concentrated and purified by flash column chromatography (silica gel, EtOAc/hexane 0%˜90%) to provide the desired product (S)-2-(3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)-imidazolidin-1-yl)ethanesulfonamide as white solid (1.2 g, 83%). 1H NMR (CDCl3, 400 MHz) δ 7.55˜7.62 (m, 3H), 7.48 (t, 1H), 7.24 (d, 2H), 7.22 (d, 2H), 6.85 (m, 4H), 5.47 (s, 2H), 5.28 (dd, 1H), 3.90˜4.03 (m, 3H), 3.40 (dd, 1H), 3.28˜3.35 (m, 2H); HPLC-MS calculated for C24H21ClF3N3O4S (M+H+) 540.1, found 540.1.

Provenance & Evidence