HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propylamine → HCID 59485694, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propylamine | HCID 7852 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 59485623 | HCID 59485623 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 59485694 | HCID 59485694 | — |
Reaction Steps
To a solution of 2-(3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)-imidazolidin-1-yl)acetic acid (16.0 mg, 0.0326 mmol), HATU (18.6 mg, 0.0489 mmol) and iPr2NEt (17.0 μL, 0.0978 mmol) in DMF (0.5 mL) is added propylamine (5.36 μL, 0.0652 mmol). The reaction mixture is stirred at room temperature overnight before removal of the solvent. The residue is purified by preparative LC/MS to provide the title compound; HPLC-MS calculated for C27H25ClF3N3O3 (M+H+) 532.2, found 532.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08431607B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-e50343582fd344ee9f82a6e5d7bdfd69 |
| Source note | uspto-grants-2013_04 |