Carbon Disulfide → HCID 59485731, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of N1-(4-(4-chlorophenoxy)phenyl)-1-(3-(trifluoromethyl)phenyl)ethane-1,2-diamine (127 mg, 0.312 mmol) in EtOH (2.0 mL) are added CS2 (188 μL, 3.12 mmol) and iPr2NEt (272 μL, 1.56 mmol). The reaction mixture is heated at 80° C. overnight before removal of the solvent. The residue is purified by silica gel chromatography (0˜40% EtOAc/Hexanes) to provide the title compound (95.9 mg, 69% yield) as a white solid product; HPLC-MS calculated for C22H16ClF3N2OS (M+H+) 449.1, found 449.1.

Provenance & Evidence