HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1972237Generated: October 31, 2026
tert-butyl(R)-1-[3-(trifluoromethyl)phenyl]-2-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)ethylcarbamate → (5R)-1-(tert-butoxycarbonyl)-5-[3-(trifluoromethyl)phenyl]-2-oxopyrrolidine-3-carboxylic acid
https://huagongshe.com/reaction/1972237
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | tert-butyl(R)-1-[3-(trifluoromethyl)phenyl]-2-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)ethylcarbamate | HCID 59485714 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | (5R)-1-(tert-butoxycarbonyl)-5-[3-(trifluoromethyl)phenyl]-2-oxopyrrolidine-3-carboxylic acid | HCID 59485976 | — |
Reaction Steps
The mixture of tert-butyl (R)-1-[3-(trifluoromethyl)phenyl]-2-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)ethylcarbamate (520 mg, 1.21 mmol) and toluene (15 mL) is stirred at 110° C. for 3 h. Concentration to give (5R)-1-(tert-butoxycarbonyl)-5-[3-(trifluoromethyl)phenyl]-2-oxopyrrolidine-3-carboxylic acid as a colorless oil. This product is used for the next step without further purification. HPLC-MS calculated for C12H10F3NO3 (M-Boc+H+) 274.06, found 274.10.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08431607B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-88470241895a45c6997e8be4aa5cd82d |
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| Source note | uspto-grants-2013_04 |
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