HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1972243Generated: October 27, 2026
(S)-methyl 4-hydroxy-4-(3-methoxyphenyl)butanoate → (S)-dihydro-5-(3-methoxyphenyl)furan-2(3H)-one
https://huagongshe.com/reaction/1972243
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | (S)-methyl 4-hydroxy-4-(3-methoxyphenyl)butanoate | HCID 59486062 | — |
| Catalyst | Trifluoroacetic acid | HCID 6422 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (S)-dihydro-5-(3-methoxyphenyl)furan-2(3H)-one | HCID 57202694 | 100% |
Reaction Steps
The (S)-methyl 4-hydroxy-4-(3-methoxyphenyl)butanoate (985 mg) is dissolved in CH2Cl2 (10 mL), and the solution is cooled to 0° C. Trifluoroacetic acid (˜4 drops) is added and the mixture is stirred for 8 h at room temperature to complete the lactonization. The reaction is quenched with aqueous sodium bicarbonate, and the organic layer is washed with water, dried (Na2SO4), and concentrated to yield 827 mg (100%) of (S)-dihydro-5-(3-methoxyphenyl)furan-2(3H)-one as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08431607B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-cfa421e281aa48c982484b61e579c722 |
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| Source note | uspto-grants-2013_04 |
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