ethyl 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxylate → 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxylic acid

HRID 197225Notes

Reaction equation

HRID 197225 reaction equation
[F:1][C:2]1([F:3])[CH2:4][CH:5]1[CH2:6][N:7]1[CH2:8][CH2:9][N:10]([c:11]2[s:12][c:13]([C:14]([O:15][CH2:16][CH3:17])=[O:18])[c:19]([CH3:20])[n:21]2)[C:22]1=[O:23].[F:24][c:25]1[cH:26][cH:27][c:28]([CH2:29][n:30]2[n:31][cH:32][n:33](-[c:36]3[s:37][c:38]([C:42](=[O:43])[O:44][CH2:45][CH3:46])[c:39]([CH3:41])[n:40]3)[c:34]2=[O:35])[cH:47][cH:48]1>>[F:24][c:25]1[cH:26][cH:27][c:28]([CH2:29][n:30]2[n:31][cH:32][n:33](-[c:36]3[s:37][c:38]([C:42](=[O:43])[OH:44])[c:39]([CH3:41])[n:40]3)[c:34]2=[O:35])[cH:47][cH:48]1

Participants

3

Reactant 2

HCID 57919964ethyl 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxylateHCID 57919981Ethyl 2-(3-((2,2-difluorocyclopropyl)methyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylate

Product 1

HCID 579198022-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxylic acid

Sources & evidence

ORD record
ord-d0b9c412464142bb960faaf45793da40
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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