4-(4-Chlorophenoxy)aniline → HCID 68705038, compound

Participants

Reaction Steps

Reference to α-amino nitrile synthesis: Synlett, 2005, 8, 1325. A methanol solution (50 mL) of 3-benzyloxybenzaldehyde (5 g, 23.6 mmol), 4-amino-4-chlorodiphenyl ether (5.7 g, 25.9 mmol), iodine (120 mg, 0.47 mmol) and trimethylsilylcyanide (3.8 mL, 28.3 mmol) is stirred at room temperature for 18 h. The precipitate that formed is collected and rinsed with ethyl acetate/hexane (1:4) to obtain ˜7 g (67%) of 2-(4-(4-chlorophenoxy)phenylamino)-2-(3-(benzyloxy)phenyl)acetonitrile as a light brown solid.

Provenance & Evidence