Aluminium lithium hydride → HCID 68704566, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of the α-amino nitrile (3 g, 6.8 mmol) from Step 1 in ether is cooled to −78° C. and is treated with lithium aluminum hydride (1.0 M solution in ether, 27.2 mmol) via slow addition. The cooling bath is removed and the reaction is allowed to warm to room temperature. Upon completion, 500 μL of water is added at 0° C. and the mixture stirred for 15 min. The mixture is filtered through a bed of Celite and the filtrate concentrated and purified by silica gel chromatography (eluting with 7N NH3 in IPA/methanol/dichloromethane 0.1:1:9) to give 1.5 g of 4-(4-chlorophenoxy)-N-(2-amino-1-(3-(benzyloxy)phenyl)ethyl)benzenamine as an oily brownish foam (50%).

Provenance & Evidence